Items for "xantines"

Correlation between plasma and urinary caffeine levels in preterm infants

Background: We hypothesize that urine levels might be reliable to assess the therapeutic range of caffeine.

Objectives: We correlated plasma and urinary levels of caffeine in preterm infants treated with this drug for apnea of prematurity.

Methods: Infants (n=56) were given a loading dose of caffeine citrate (10 mg/kg, per os) and 24 h later a maintenance dose (2 mg/kg, per os, once a day)...

Keywords: Apnea of prematurity, caffeine, urinary excretion of caffeine, xantines