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von Willebrand factor
Items for "von Willebrand factor"
Relatively increased von Willebrand factor activity after off-pump coronary artery bypass graft surgery
High shear forces can induce structural changes in the shape of the von Willebrand factor (VWF) molecule, making it more sensitive for ADAMTS-13, a specific VWF protease...
Keywords: von Willebrand factor, hypercoagulability, proteases / inhibitors, acquired coagulation disorders
01/2007 | Thrombosis and Haemostasis, SchattauerPrimary haemostasis and its assessment by laboratory tests
Platelets constantly patrol the inner surface of blood vessels searching leaks to be sealed, in order to prevent blood loss...
Keywords: Thrombozyten, Adhäsion, Aggregation, von-Willebrand- Faktor
01/2006 | Hämostaseologie, SchattauerAntiviral therapy decreases GpIIb/IIIa activation of platelets in patients with chronic hepatitis C
Interferon alpha (IFN-) is used to treat haematological and solid malignancies and is the gold standard therapy for chronic hepatitis C infection in combination with ribavirin...
Keywords: Platelet activation markers, von Willebrand factor, clinical / epidemiological studies
00/0000 | Thrombosis and Haemostasis, SchattauerImpaired dimerization of von Willebrand factor subunit due to mutation A2801D in the CK domain results in a recessive type 2A subtype IID von Willebrand disease
The CK domain of von Willebrand factor (VWF) is involved in the dimerization of the protein. We identified the homozygous substitution A2801D of the CK domain in two siblings...
Keywords: von Willebrand factor, von Willebrand disease, type 2A VWF, dimerization, CK domain
05/2006 | Thrombosis and Haemostasis, SchattauerEndothelial dysfunction and systemic inflammation in persons with echolucent carotid plaques
Echolucent carotid plaques are associated with high risk for future ischemic cerebrovascular events independent of the degree of stenosis...
Keywords: atherosclerosis, ultrasound / diagnosis, von Willebrand factor, plasminogen activators, Cerebrovascular disease
07/2006 | Thrombosis and Haemostasis, SchattauerType 2N von Willebrand disease due to compound heterozygosity for R854Q and a novel R763G mutation at the cleavage site of von Willebrand factor propeptide
Type 2N von Willebrand disease (VWD) is characterized by a markedly decreased affinity of von Willebrand factor (VWF) for factorVIII (FVIII) and is caused by mutations in the D or D3 domain of mature VWF...
Keywords: von Willebrand factor, von Willebrand disease, mutation, cleavage site
09/2006 | Thrombosis and Haemostasis, SchattauerCombined partial exon skipping and cryptic splice site activation as a new molecular mechanism for recessive type 1 von Willebrand disease
We describe the complex picture associated with a mutated splice junction in intron 13 of von Willebrand factor (VWF) gene...
Keywords: von Willebrand factor, von Willebrand disease, VWF mRNA, VWF mutations
12/2006 | Thrombosis and Haemostasis, SchattauerAltered von Willebrand factor subunit proteolysis and multimer processing associated with the Cys2362Phe mutation in the B2 domain
The normal von Willebrand factor (vWF) multimer pattern results from the ADAMTS-13 cleavage of the Tyr 1605-Met 1606 bond in the A2 domain of vWF...
Keywords: von Willebrand factor, von Willebrand disease, vWF multimers, vWF proteolysis, vWF processing
04/2007 | Thrombosis and Haemostasis, SchattauerABO blood group genotypes, plasma von Willebrand factor levels and loading of von Willebrand factor with A and B antigens
ABO blood group is a genetic determinant of von Willebrand factor (VWF) levels. We investigated the effect of ABO genotypes on VWF and factor VIII (FVIII) levels and on the degree to which VWF is loaded with A- and B-antigens, expressed as normalized ratios, nA-ratio and nB-ratio, respectively, in the Leiden Thrombophilia Study, a large case-control study on venous thrombosis...
Keywords: ABO genotypes, von Willebrand factor, A and B antigens
04/2007 | Thrombosis and Haemostasis, SchattauerPerformance and utility of a cost-effective collagen-binding assay for the laboratory diagnosis of Von Willebrand disease
Keywords: collagen-binding assay, von Willebrand disease, Von Willebrand disorder, von Willebrand factor
08/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterInteraktion des von Willebrand Faktors mit Thrombozyten und der Gefäßwand. Interaction of von Willebrand factor and platelets at the vessel wall
Keywords: Adhäsion, Scherrate, Strömung, Thrombozyten, von Willebrand Faktor, adhesion, platelets, shear rate, von Willebrand factor
12/2004 | LaboratoriumsMedizin, Walter de Gruyter