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Items for "vitamin B12"

A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry

Background: Cobalamin (Cbl) deficiency is a common clinical phenomenon, in particular among the elderly and possibly also among infants...

Keywords: cobalamin, homocysteine, liquid chromatography-electrospray ionization tandem mass spectrometry, methylmalonic acid (MMA), vitamin B12

05/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Justifying the “Folate trap” in folic acid fortification programs

Many countries have now adopted fortification, where folic acid is added to flour and intended to benefit all with rise in blood folate level...

Keywords: Folate trap, folic acid fortification, vitamin B12

06/2007 | Journal of Perinatal Medicine, Walter de Gruyter
Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease

The association between elevated plasma levels of homocysteine (Hcy) and nutritional status has been shown in Alzheimer disease (AD) patients and also in vascular dementia (VaD)...

Keywords: Alzheimer disease, folate, homocysteine, vascular dementia, vitamin B12

09/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy

Mild hyperhomocysteinemia is established as an independent risk factor for atherothrombotic disease, including ocular pathologies such as retinal vascular occlusion and non-arteritic ischemic optic neuropathy (NAION)...

Keywords: cystathionine, folic acid, homocysteine, methylmalonic acid, renal function, retinal vascular occlusion, vitamin B12

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients

The role of hyperhomocysteinemia (HHcy) as a risk marker for cardiovascular diseases in renal patients is a matter of controversy...

Keywords: homocysteine, methylmalonic acid, renal patients, vitamin B12

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population

Prevalence rates for folate deficiency and hyperhomocysteinemia have been markedly reduced following the introduction of folic acid fortification in the United States...

Keywords: folate, fortification, homocysteine, transcobalamin, vitamin B12, PAR%, population attributable risk percentage, SALSA, Sacramento Area Latino Study on Aging

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects

Studies linking hyperhomocysteinemia (HHCY) and B-vitamin deficiency to some health aspects in children have been accumulating...

Keywords: folate, homocysteine, Pediatrics, vitamin B12

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Homocysteine and B vitamins in mild cognitive impairment and dementia

Elderly subjects with mild cognitive impairment have a high risk for conversion to Alzheimer's disease or are already in a preclinical dementia stage...

Keywords: dementia, folate, homocysteine, mild cognitive impairment, vitamin B12

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Maine-Syracuse Study

Type 2 diabetes mellitus and higher total plasma homocysteine concentrations are each associated with an increased incidence of cardiovascular disease and with diminished cognitive performance...

Keywords: cardiovascular risk factors, cognitive performance, Diabetes mellitus, folate, homocysteine, vitamin B12, vitamin B6

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
The potential cocarcinogenic effect of vitamin B12 deficiency

Since vitamin B12 serves as a cofactor in the synthesis of methyl precursors for biological methylation and enables methylfolate to be recycled for nucleotide synthesis, B12 deficiency has been known to induce hyperhomocysteinemia and inadequate DNA synthesis, along with “methylfolate trap”...

Keywords: Cancer, DNA methylation, folate, one-carbon metabolism, uracil misincorporation into DNA, vitamin B12

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
The vegetarian lifestyle and DNA methylation

Vegetarians have a lower intake of vitamin B12 than omnivores do. Vitamin B12 deficiency (holotranscobalamin II <35 pmol/L or methylmalonic acid >271 nmol/L) was found in 58% of 71 vegetarians studied...

Keywords: DNA methylation, homocysteine, Pyrosequencing?, vegetarians, vitamin B12

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Hyperhomocysteinaemia and immune activation in patients with cancer

Background: Recently, homocysteine production was observed in tumour cell lines and homocysteine was proposed as a tumour marker...

Keywords: Cancer, cysteine, folate, homocysteine, inflammation, neopterin, vitamin B12

01/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily

Background: Homocysteine is associated with age, folate and vitamin B12...

Keywords: aging, folate, peripheral arteriopathy, Stroke, vitamin B12

02/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: a population-based study in Sicily

Background: Association of thyroid dysfunction with plasma homocysteine levels and vitamin B12 has previously been reported...

Keywords: folate, homocysteine, thyroid dysfunction, vitamin B12

02/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
International Standard for serum vitamin B12 and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B12 and folate content

Background: Vitamin B12 and folate measurements in serum show wide inter-methodology variability...

Keywords: folate, liquid chromatography coupled to isotope-dilution tandem mass spectrometry (LC/MS/MS), 5-methyl tetrahydrofolic acid (5MeTHF), reference, standardisation, vitamin B12

03/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women

Background: Hyperhomocysteinemia and B-vitamin deficiency are associated with recurrent abortion...

Keywords: homocysteine, methylmalonic acid, recurrent pregnancy loss, vitamin B12

09/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis

Background: Elevated plasma total homocysteine is a risk factor for cardiovascular disease (CVD), but the randomized trials of dietary supplementation with B-vitamins to lower homocysteine have not yet provided clear evidence of benefit on vascular risk.

Methods: Cumulative meta-analysis of all randomized trials assessing the effects of lowering homocysteine levels with B-vitamins on risk of CVD.

Results: An individual patient data meta-analysis of all randomized trials of the effects on vascular risk of lowering homocysteine with B-vitamins will maximize the power to assess the epidemiologically predicted differences in risk...

Keywords: folic acid, homocysteine, meta-analysis, trials, vitamin B12

12/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial

Background: Hyperhomocysteinemia is a new risk factor for osteoporosis...

Keywords: bone mineral density, C-terminal telopeptides of collagen I (CTx), folate, homocysteine, osteocalcin, pro-collagen type I N-terminal peptide (PINP), tartrate-resistant acid phosphatase (TRAP), urinary desoxypyridinoline cross-links (DPD), vitamin B6, vitamin B12

12/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review

Hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis...

Keywords: bone metabolism, folate, homocysteine, Osteoporosis, vitamin B6, vitamin B12

12/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter