SARS-coronavirus (SARS-CoV) encodes a main protease, 3CLpro, which plays an essential role in the viral life cycle and is currently the prime target for discovering new anti-coronavirus agents...
Keywords: fluorescence-based protease assay, internally quenched fluorogenic peptide substrate, SARS-coronavirus 3CL protease, viral protease, viral protease inhibitor
08/2006 | Biological Chemistry, Walter de GruyterThe study of host and viral membrane-associated proteases has been hampered due to a lack of
Keywords: activity-based probe, cell-based assay, Discosoma red fluorescent protein, intracellular proteolysis, juxtamembrane protease, membrane-bound serine protease, viral protease
08/2006 | Biological Chemistry, Walter de Gruyter