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Items for "vascular endothelium"

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region

Fluid shear stress is crucial for maintenance of a properly functioning endothelium...

Keywords: mechanical stress, promoter region, transcription factor, vascular endothelium

08/2004 | Biological Chemistry, Walter de Gruyter
A1166C polymorphism of the angiotensin AT1 receptor (AT1R) gene alters endothelial response to statin treatment

Background: The function of vascular endothelium is influenced by several factors: low-density lipoprotein (LDL) cholesterol, oxidative stress and the reninangiotensin system.

Methods: We tested the hypothesis that polymorphisms A1166C of the angiotensin AT1 receptor (AT1R) gene, C242T and A640G of the pphox22 gene (p22 phox is an essential component of NADH/NADPH oxidases) and G894T of the endothelial nitric oxide (NO) synthase (eNOS) gene influence endothelial function and its reaction to statin treatment...

Keywords: genetic polymorphisms, statin treatment, vascular endothelium

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter