Inadequate folate intake and aging are each strongly implicated as important risk factors for certain cancers...
Keywords: aging, carcinogenesis, DNA methylation, folate, one-carbon metabolism, uracil misincorporation into DNA
10/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterSince vitamin B12 serves as a cofactor in the synthesis of methyl precursors for biological methylation and enables methylfolate to be recycled for nucleotide synthesis, B12 deficiency has been known to induce hyperhomocysteinemia and inadequate DNA synthesis, along with “methylfolate trap”...
Keywords: Cancer, DNA methylation, folate, one-carbon metabolism, uracil misincorporation into DNA, vitamin B12
10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter