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Items for "ubiquitin"

Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system

The sodium taurocholate cotransporting polypeptide (Ntcp, Slc10a1) is the major uptake system for bile acids into liver cells...

Keywords: aggresome, integral membrane proteins, N-linked glycosylation, proteasome, proteolysis, ubiquitin

10/2005 | Biological Chemistry, Walter de Gruyter

Impact of the N-terminal amino acid on targeted protein degradation

The N-terminus of any protein may be used as a destabilization signal for targeted protein degradation...

Keywords: aminopeptidase, co-translational, deformylase, leucine, Methionine, proteasome, protein, ubiquitin

07/2006 | Biological Chemistry, Walter de Gruyter

Structural aspects of recently discovered viral deubiquitinating activities

Protein ubiquitination has been identified as a regulatory mechanism in key cellular activities, and deubiquitination is recognized as an important step in processes governed by ubiquitin and ubiquitin-like modifiers...

Keywords: adenovirus protease, herpesvirus UL36 tegument protein, protein structure comparison, SARS coronavirus papain-like protease, ubiquitin, ubiquitin-like modifiers

07/2006 | Biological Chemistry, Walter de Gruyter

Diversity of proteasomal missions: fine tuning of the immune response

The majority of cellular proteins are degraded by proteasomes within the ubiquitin-proteasome ATP-dependent degradation pathway...

Keywords: antigen, ?-interferon, MHC class I, Ntn hydrolase, splicing, ubiquitin