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Items for "type 2 diabetes"

Prevention of diabetes mellitus: The future of German diabetology

One of the challenges in clinical diabetology today is to develop and implement diabetes prevention management programs for clinical practice...

Keywords: Diabetes mellitus, Glukosetoleranz, Lebensstilintervention Typ-2-Diabetes, nationales Programm

01/2007 | Hämostaseologie, Schattauer
The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy

Both insulin-dependent (type 1) and insulin-independent (type 2) diabetes are complex disorders characterized by symptomatic glucose intolerance due to either defective insulin secretion, insulin action or both...

Keywords: bradykinin B1 receptor, hyperalgesia, kinins, neuropathy, nociception, type 1 diabetes, type 2 diabetes

02/2006 | Biological Chemistry, Walter de Gruyter
Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-&ggr;2 (PPAR&ggr;-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population

Background: The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-&ggr;2 (PPAR&ggr;-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations...

Keywords: insulin resistance, Iranian population, obesity, peroxisome proliferator-activated receptor-2 (PPAR-2), Pro12Ala, type 2 diabetes

04/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Association of high-sensitive C-reactive protein with advanced stage ?-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus

Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk...

Keywords: high-sensitivity C-reactive protein (hsCRP), homeostatic model assessment (HOMA), insulin resistance, intact proinsulin, type 2 diabetes

05/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review

The current worldwide prevalence of type 2 diabetes (T2D) was estimated to be 2.8% in 2000, but it is predicted to increase to epidemic proportions in the coming decades, primarily due to lifestyle changes, particularly obesity...

Keywords: genetic testing, motivation, obesity, type 2 diabetes

03/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Comparability of indices for insulin resistance and insulin secretion determined during oral glucose tolerance tests

Background: Impaired insulin secretion (IS) and insulin resistance (IR) play an essential role in the pathogenesis of type 2 diabetes mellitus...

Keywords: glucose tolerance test, insulin indices, insulin resistance, insulin sensitivity, type 2 diabetes

07/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Carbonylation of platelet proteins occurs as consequence of oxidative stress and thrombin activation, and is stimulated by ageing and type 2 diabetes

Background: In normal ageing, as well as in diabetes mellitus, blood platelets are exposed to increasing amounts of reactive oxygen species...

Keywords: ageing, oxidative stress, thrombin, type 2 diabetes

04/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
The apolipoprotein A5 gene –1131T?C polymorphism affects vitamin E plasma concentrations in type 2 diabetic patients

Background: Variations of the apolipoprotein A5 (APOA5) gene are strongly associated with hypertriglyceridemia...

Keywords: APOA5, Oxidation, triglycerides, type 2 diabetes, vitamin E

04/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Sub-chronic administration of the 11?-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity

We have examined the metabolic effects of daily administration of carbenoxolone (CBX), a naturally occurring 11?-hydroxysteroid dehydrogenase (11?-HSD1) inhibitor, in mice with high fat diet-induced insulin resistance and obesity...

Keywords: carbenoxolone (CBX), glucose tolerance, 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1), insulin sensitivity, obesity, type 2 diabetes

04/2008 | Biological Chemistry, Walter de Gruyter
Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue

Pseudin-2 is a cationic ?-helical peptide that was first isolated from the skin of the paradoxical frog Pseudis paradoxa on the basis of its antimicrobial activity...

Keywords: frog skin, insulin secretion, pseudin-2, type 2 diabetes

02/2008 | Biological Chemistry, Walter de Gruyter
The ?374A allele of the receptor for advanced glycation end products (RAGE) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients

Background: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been associated with diabetes, coronary artery disease (CAD) and inflammatory processes...

Keywords: advanced glycation end products, coronary artery disease, disease severity, Euro-Brazilians, risk factor, single nucleotide polymorphism, type 2 diabetes

10/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter