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Items for "transitional study"

A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio

Cytochrome P450 (CYP) is a multigene family of enzymes involved in important life functions; some of these genes are inducible and are implicated in the oxidative metabolic activation and detoxification of many endogenous and exogenous compounds. CYP1B1 codes for an enzyme that catalyses the production of a 2- and 4-hydroxyl group in estrone and estradiol, while CYP1A1 catalyzes the 2-hydroxylation of estradiol in endometrium...

Keywords: chemoprevention, epidemiology, estrogen metabolism, transitional study

07/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter