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Items for "transcriptional regulation"

Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells

Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis...

Keywords: connective tissue growth factor (CTGF), extracellular matrix, mesangial cells, nitric oxide, representational difference analysis (RDA), transcriptional regulation

05/2007 | Biological Chemistry, Walter de Gruyter

Activation of the glutathione peroxidase 2 (GPx2) promoter by ?-catenin

GPx2, formerly named gastrointestinal glutathione peroxidase, is highly expressed in the proliferative area of the intestinal crypt-to-villus axis and in Paneth cells...

Keywords: ?-catenin, carcinogenesis, gastrointestinal glutathione peroxidase (GPx2), proliferation, selenoproteins, transcriptional regulation

10/2007 | Biological Chemistry, Walter de Gruyter

Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3

The constitutive androstane receptor (CAR) is a member of the nuclear receptor superfamily and plays an important role in the degradation of xenobiotics in the liver...

Keywords: co-repressor, nuclear receptor, transcriptional regulation

10/2008 | Biological Chemistry, Walter de Gruyter

Role of histone modifications in defining chromatin structure and function

Chromosomes in eukaryotic cell nuclei are not uniformly organized, but rather contain distinct chromatin elements, with each state having a defined biochemical structure and biological function...

Keywords: chromatin function, chromatin structure, euchromatin, heterochromatin, post-translational modification, transcriptional regulation