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Items for "transcription factor"

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region

Fluid shear stress is crucial for maintenance of a properly functioning endothelium...

Keywords: mechanical stress, promoter region, transcription factor, vascular endothelium

08/2004 | Biological Chemistry, Walter de Gruyter

Single zinc-finger extension: enhancing transcriptional activity and specificity of three-zinc-finger proteins

In order to demonstrate that an existing zinc-finger protein can be simply modified to enhance DNA binding and sequence discrimination in both episomal and chromatin contexts using existing zinc-finger DNA recognition code data, and without recourse to phage display and selection strategies, we have examined the consequences of a single zinc-finger extension to a synthetic three-zinc-finger VP16 fusion protein, on transcriptional activation from model target promoters harbouring the zinc-finger binding sequences...

Keywords: array extension, DNA binding, four zinc-finger protein, transactivation, transcription factor

02/2005 | Biological Chemistry, Walter de Gruyter

Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains

FOXM1c (MPP2) is an activating transcription factor with several nuclear localization signals, a forkhead domain for DNA binding, and a very strong acidic transactivation domain...

Keywords: forkhead box, FOXM1c, transactivation domain, transcription factor, transrepression domain, winged helix

07/2006 | Biological Chemistry, Walter de Gruyter

A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L

The Cut-like genes code for multiple isoforms of the CDP/Cux transcription factor...

Keywords: cathepsin L, CDP/Cux, cellular proliferation, cysteine proteases, proteolytic processing, transcription factor

09/2006 | Biological Chemistry, Walter de Gruyter

The c.–292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective

Background: Reticulocyte-type 15-lipoxygenase-1 (ALOX15) has anti-inflammatory and inflammatory effects and is implicated in the development of asthma, arthritis and atherosclerosis...

Keywords: inflammation, lipoxin, 15-lipoxygenase (15-LOX), Polymorphism, PU.1, reticulocyte-type 15-lipoxygenase-1 (ALOX15), SFPI1, SPI1, transcription factor

04/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

HNF4? orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells

Few genes are known to be involved in renal cell carcinoma (RCC) development and progression...

Keywords: esiRNA, HEK293 cells, HNF4?-regulated genes, renal cell carcinoma, RNA interference, transcription factor

02/2008 | Biological Chemistry, Walter de Gruyter

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