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transactivation
Items for "transactivation"
GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptor
The androgen receptor (AR) mediates transactivation of target genes by acting as a dimer in which its amino-terminal domain (AR-NTD) interacts with its carboxyl-terminal, ligand-binding domain (AR-LBD) (N/C interaction)...
Keywords: androgen receptor, coactivator, dimerization, domain interactions, transactivation, transcription
01/2005 | Biological Chemistry, Walter de GruyterSingle zinc-finger extension: enhancing transcriptional activity and specificity of three-zinc-finger proteins
In order to demonstrate that an existing zinc-finger protein can be simply modified to enhance DNA binding and sequence discrimination in both episomal and chromatin contexts using existing zinc-finger DNA recognition code data, and without recourse to phage display and selection strategies, we have examined the consequences of a single zinc-finger extension to a synthetic three-zinc-finger VP16 fusion protein, on transcriptional activation from model target promoters harbouring the zinc-finger binding sequences...
Keywords: array extension, DNA binding, four zinc-finger protein, transactivation, transcription factor
02/2005 | Biological Chemistry, Walter de GruyterAryl hydrocarbon receptor agonists directly activate estrogen receptor ? in MCF-7 breast cancer cells
The aryl hydrocarbon receptor (AhR) binds with high affinity to 2,3,7,8-tetrachlorodibenzo-
Keywords: AhR, estrogenicity, selective AhR modulators, transactivation
09/2006 | Biological Chemistry, Walter de Gruyter