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Tissue factor
Items for "Tissue factor"
Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer
The pathogenesis of hypercoagulability in cancer is not entirely understood. We hypothesized that in cancer patients circulating tissue factor-positive microparticles (TF + MPs) are increased and associated with hemostatic system activation...
Keywords: Cancer, microparticles, Tissue factor, hemostasis, platelets
01/2007 | Thrombosis and Haemostasis, SchattauerTissue factor in acute coronary syndromes
Rupture of an atherosclerotic plaque with subsequent thrombosis and myocardial ischemia is the pathopysiological mechanism in acute coronary syndromes...
Keywords: Tissue-Faktor, Akutes Koronarsyndrom, Blutgerinnung
01/2006 | Hämostaseologie, SchattauerNew locations of intravascular tissue factor: Indications
Tissue factor (TF) is the major initiator of blood coagulation, and a mediator of inflammation, angiogenesis, and carcinogenesis...
Keywords: Tissue-Faktor, Gewebethromboplastin, Blutgerinnung, Enkryptierung, Aktivierung, Plättchen, Monozyten, Eosinophile, Neutrophile, Mikropartikel, intravasal, Entzündung
01/2007 | Hämostaseologie, SchattauerDifferential expression of tissue factor mRNA and protein expression in murine sepsis. The role of the granulocyte revisited
Tissue factor (TF) is a transmembrane protein, which is essential for initiation of the coagulation cascade...
Keywords: Tissue factor, Coagulation, sepsis, inflammation, granulocytes
00/0000 | Thrombosis and Haemostasis, SchattauerAntithrombotic properties of Ixolaris, a potent inhibitor of the extrinsic pathway of the coagulation cascade
Ixolaris is a two-Kunitz tick salivary gland protein identified in Ixodes scapularis that presents extensive sequence homology to TFPI...
Keywords: Anticoagulant, ixolaris, Venous thrombosis, factor Xa, Tissue factor, tick saliva, Ixodes scapularis
07/2006 | Thrombosis and Haemostasis, SchattauerFlow cytometry-sorted non-viable endotoxin-treated human monocytes are strongly procoagulant
Monocytes/macrophages are important in disease states such as gram-negative sepsis and coronary artery disease...
Keywords: Tissue factor, Coagulation, phosphatidylserine, monocyte, sorting flow cytometry
07/2006 | Thrombosis and Haemostasis, SchattauerAmplified anticoagulant activity of tissue factor-targeted thrombomodulin. In-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulin
Tissue factor (TF) exposure is a potent pro-thrombotic trigger that initiates activation of the coagulation cascade, while thrombomodulin (TM) is a potent anticoagulant protein that limits the extent of activation...
Keywords: Tissue factor, thrombomodulin, fusion protein, Anticoagulant, rat thromboembolism
09/2006 | Thrombosis and Haemostasis, SchattauerFormation of tissue factor-factor VIIa-factor Xa complex prevents apoptosis in human breast cancer cells
Tissue factor (TF) is a transmembrane glycoprotein that initiates blood coagulation when complexed with factor VIIa (FVIIa)...
Keywords: Apoptosis, breast cancer, factor VIIa, factor Xa, Tissue factor
08/2006 | Thrombosis and Haemostasis, SchattauerPlatelet activation and high tissue factor level predict acute stent thrombosis in pig coronary arteries: Prothrombogenic response of drug-eluting or bare stent implantation within the first 24 hours
Increased thrombogenicity of drug-eluting stents (DESs) has recently been reported. The aim of the present study was to investigate the prothrombogenic effect of DESs and Bare stents, and determine factors predictive of acute stent thrombosis (AST) in preclinical experiments using new stent design or coating...
Keywords: platelets, stents,thrombosis, coronary circulation, Tissue factor
08/2006 | Thrombosis and Haemostasis, SchattauerEffect of antiplatelet agents clopidogrel, aspirin, and cilostazol on circulating tissue factor procoagulant activity in patients with peripheral arterial disease
Tissue factor (TF) is the physiological initiating mechanism for blood coagulation. Platelets play an important role in monocyte TF expression, thrombosis and inflammation...
Keywords: Aspirin, Clopidogrel, Tissue factor, peripheral vascular disease, platelets
12/2006 | Thrombosis and Haemostasis, SchattauerEthyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells
Sepsis is characterized by a concurrent activation of inflammation and coagulation. Recently, recombinant human activated protein C was shown to decrease mortality in patients with severe sepsis presumably due to a combined anti-inflammatory and anticoagulant effect...
Keywords: Tissue factor, ethyl pyruvate, sepsis, lipopolysaccharide, THP-1 monocytic cells
12/2006 | Thrombosis and Haemostasis, SchattauerTissue factor-enriched vesicles are taken up by platelets and induce platelet aggregation in the presence of factor VIIa
We investigated the interactions of vesicles containing human tissue factor (TF) with platelets and evaluated responses induced by rFVIIa using standard aggregometry, ultrastructural and flow-cytometry techniques...
Keywords: platelets, Tissue factor, vesicles, traffic, rFVIIa
00/0000 | Thrombosis and Haemostasis, SchattauerMonocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles
Lipopolysaccharide (LPS)-stimulated monocytes are known to have a procoagulant effect. This property is currently explained by the fact that monocytes, in response to LPS, can express tissue factor (TF) and undergo a process of membrane microvesiculation...
Keywords: interleukin-10, monocytes, thrombin generation, Tissue factor, microparticles
04/2007 | Thrombosis and Haemostasis, SchattauerHigh-affinity antibodies in a new immunoassay for plasma tissue factor: reduction in apparent intra-individual variation
Tissue factor, the main initiator of blood coagulation, is shed into plasma by blood cells and endothelium...
Keywords: antibody affinity, ELISA, Thromboplastin, Tissue factor
12/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter