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Items for "Tissue-type plasminogen activator"

Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of Gq, PLC-, IP3 and 5,6-epoxyeicosatrienoic acid

The acute physiologic release of tissue-type plasminogen activator (t-PA) from the endothelium is critical for vascular homeostasis...

Keywords: Tissue-type plasminogen activator, signal transduction, pharmacology, thrombin, protease-activated receptor, epoxyeicosatrienoic acids (EET’s)

00/0000 | Thrombosis and Haemostasis, Schattauer
Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability

Background: Measurement of some haemostatic factors and products formed during activation of haemostasis seems to be promising in the determination of hypercoagulability.

Methods: The fibrinolytic variables euglobulin clot lysis time, tissue-type plasminogen activator, plasminogen activator inhibitor-1 and the haemostasis activation markers prothrombin fragment 1+2, thrombin-antithrombin complex and D-dimer were determined in 101 apparently healthy men and women aged 20–92 years (58±18 years, mean±SD) to establish variability due to several demographic, behavioural and metabolic factors.

Results: None of the fibrinolytic variables were affected by smoking, while tissue-type plasminogen activator antigen was significantly lower in women compared to men...

Keywords: D-dimer, fibrinolysis, plasminogen activator inhibitor-1, prothrombin fragment 1+2, thrombin-antithrombin complex, Tissue-type plasminogen activator

01/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter