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Items for "thrombomodulin"

Amplified anticoagulant activity of tissue factor-targeted thrombomodulin. In-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulin

Tissue factor (TF) exposure is a potent pro-thrombotic trigger that initiates activation of the coagulation cascade, while thrombomodulin (TM) is a potent anticoagulant protein that limits the extent of activation...

Keywords: Tissue factor, thrombomodulin, fusion protein, Anticoagulant, rat thromboembolism

09/2006 | Thrombosis and Haemostasis, Schattauer

Use of calibrated automated thrombinography thrombomodulin to recognise the prothrombotic phenotype

There is currently no validated method to detect a prothrombotic phenotype. The question remains, can tissue factor (TF) induced thrombin generation (TG), as measured with the calibrated automated thrombinography (CAT) technique, according to Hemker et al., recognise a prothrombotic state either as such, or when the activated protein C (APC)-system is boosted with thrombomodulin (TM)? We determined the normal range of CAT-TG TM in a group of 71 healthy blood donors, in 11 healthy women using oral contraceptives (OC), and in 89 patients with a history of venous thromboembolism (VTE), divided into a group of 50 in which a prothrombotic risk factor could be found (VTEprf+) and 39 others (VTEprf-)...

Keywords: thrombin generation, thrombomodulin, hypercoagulability, calibrated automated thrombogram,venous thromboembolism

11/2006 | Thrombosis and Haemostasis, Schattauer

Remodeling of carotid arteries is associated with increased expression of thrombomodulin in a mouse transverse aortic constriction model

Thrombomodulin (TM) is an endothelial glycoprotein that functions as a thrombin cofactor in the activation of protein C...

Keywords: arterial remodeling, atherosclerosis, thrombomodulin

04/2007 | Thrombosis and Haemostasis, Schattauer

Protein C, protein S, and thrombomodulin in amniotic fluid. A preliminary study

Objectives: The main components of protein C anticoagulant system are protein C (PC), protein S (PS) and thrombomodulin (TM); the system plays a protective role in pregnancy, mainly because it prevents the utero–placental circulation from local thrombosis...

Keywords: amniotic fluid, Protein C, protein S, thrombomodulin