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thrombin generation
Items for "thrombin generation"
Hyperprothrombinaemia-induced APC resistance: Differential influence on fibrin formation and fibrinolysis
The prothrombin gene mutation G20210A is a common risk factor for thrombosis and has been reported to cause APC resistance...
Keywords: Protein C, prothrombin G20210A, TAFI, thrombin generation, thrombosis
04/2006 | Thrombosis and Haemostasis, SchattauerAge-dependency of thrombin generation measured by means of calibrated automated thrombography (CAT)
Many coagulation parameters, such as PT or aPTT, show agedependency. In this study we investigated if the generation of thrombin, possibly better reflecting overall haemostasis, shows an age-dependency...
Keywords: thrombin generation, calibrated automated thrombography, age-dependency
05/2006 | Thrombosis and Haemostasis, SchattauerSerum osteoprotegerin in young survivors of myocardial infarction
Osteoprotegerin (OPG) is a member of the tumour necrosis factor superfamily and is involved in the regulation of bone metabolism and vascular calcification...
Keywords: osteoprotegerin, homocysteine, Coagulation, thrombin generation, myocardial infarction
05/2006 | Thrombosis and Haemostasis, SchattauerThrombin generation, a function test of the haemostatic-thrombotic system
By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%)...
Keywords: thrombin generation, hypercoagulability, antithrombotics, Haemophilia
11/2006 | Thrombosis and Haemostasis, SchattauerUse of calibrated automated thrombinography thrombomodulin to recognise the prothrombotic phenotype
There is currently no validated method to detect a prothrombotic phenotype. The question remains, can tissue factor (TF) induced thrombin generation (TG), as measured with the calibrated automated thrombinography (CAT) technique, according to Hemker et al., recognise a prothrombotic state either as such, or when the activated protein C (APC)-system is boosted with thrombomodulin (TM)? We determined the normal range of CAT-TG TM in a group of 71 healthy blood donors, in 11 healthy women using oral contraceptives (OC), and in 89 patients with a history of venous thromboembolism (VTE), divided into a group of 50 in which a prothrombotic risk factor could be found (VTEprf+) and 39 others (VTEprf-)...
Keywords: thrombin generation, thrombomodulin, hypercoagulability, calibrated automated thrombogram,venous thromboembolism
11/2006 | Thrombosis and Haemostasis, SchattauerPlatelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets
Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems...
Keywords: Platelet, PMPs, procoagulant activity, spatial dynamics of coagulation, thrombin generation, factor X, phosphatidylserine, CD-61, CD-62P
03/2007 | Thrombosis and Haemostasis, SchattauerMonocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles
Lipopolysaccharide (LPS)-stimulated monocytes are known to have a procoagulant effect. This property is currently explained by the fact that monocytes, in response to LPS, can express tissue factor (TF) and undergo a process of membrane microvesiculation...
Keywords: interleukin-10, monocytes, thrombin generation, Tissue factor, microparticles
04/2007 | Thrombosis and Haemostasis, Schattauer