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Items for "thrombin"

Fibrin monomer and factor XIII: a new concept for unexplained intraoperative coagulopathy

Unexplained intraoperative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intraoperative coagulopathies is of great variety and complexity (preexisting coagulopathies, dilutional coagulopathy, interactions of medications etc.)...

Keywords: Thrombin, Fibrinmonomer, FXIII, Gerinnselfestigkeit, intraoperativer Blutverlust

01/2006 | Hämostaseologie, Schattauer

Modulation of protease nexin-1 activity by polysaccharides

Protease nexin-1 (PN-1) is a non-circulating pericellular serpin expressed by vascular cells. PN-1 inhibits different proteases but when associated with glycosaminoglycans, its activity is mainly directed towards thrombin...

Keywords: Protease nexin-1, thrombin, smooth muscle cells, polysaccharides, fucoidans

00/0000 | Thrombosis and Haemostasis, Schattauer

The procoagulant effects of factor V Leiden may be balanced against decreased levels of factor V and do not reflect in vivo thrombin formation in newborns

Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor VLeiden (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns...

Keywords: Newborn, thrombin, activated protein C, factor V Leiden, platelet- rich plasma

03/2006 | Thrombosis and Haemostasis, Schattauer

Truncated and microparticle-free soluble tissue factor bound to peripheral monocytes preferentially activate factor VII

Soluble plasma tissue factor (TF) circulates in picomolar concentrations in healthy individuals and increases in a wide spectrum of diseases...

Keywords: Soluble tissue factor, monocytes, platelets, thrombin

03/2006 | Thrombosis and Haemostasis, Schattauer

Less pronounced enhancement of thrombin-dependent inactivation of plasminogen activator inhibitor type 1 by low molecular weight heparin compared with unfractionated heparin

Plasminogen activator inhibitor type 1 (PAI-1), the primary inhibitor of plasminogen activators, also forms high molecular weight complexes with either thrombin or factor Xa (FXa) in the presence of heparin, resulting in the loss of mutual activities of enzyme and inhibitor...

Keywords: Plasminogen activator inhibitor type 1,low molecular weight heparin, unfractionated heparin, thrombin, vitronectin

04/2006 | Thrombosis and Haemostasis, Schattauer

Review: Laboratory markers quantifying prothrombin activation and actions of thrombin in venous and arterial thrombosis do not accurately assess disease severity or the effectiveness of treatment

Thrombin is normally produced for hemostasis and physiological wound healing. Increased thrombin production in vivo, cell activation and inflammation mediated in part by thrombin are hallmarks of both arterial and venous thrombosis...

Keywords: thrombin, prothrombin fragment 1 + 2, arterial and venous thrombosis, platelets

11/2006 | Thrombosis and Haemostasis, Schattauer

Exchange transfusion activates coagulation and alters the coagulation profile in newborn infants

Exchange transfusion (ET) with adult blood is a standard procedure for neonates with severe hyperbilirubinemia...

Keywords: blood coagulation, exchange transfusion, Newborn, Protein C, thrombin

08/2006 | Thrombosis and Haemostasis, Schattauer

Platelet microparticle formation and thrombin generation under high shear are effectively suppressed by a monoclonal antibody against GPIba

We studied the inhibition of platelet microparticle (MP) formation and thrombin generation under high shear forces...

Keywords: Platelet microparticles, platelet glycoprotein Ib, thrombin, high shear, antiplatelet agents

12/2006 | Thrombosis and Haemostasis, Schattauer

Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of Gq, PLC-, IP3 and 5,6-epoxyeicosatrienoic acid

The acute physiologic release of tissue-type plasminogen activator (t-PA) from the endothelium is critical for vascular homeostasis...

Keywords: Tissue-type plasminogen activator, signal transduction, pharmacology, thrombin, protease-activated receptor, epoxyeicosatrienoic acids (EET’s)

00/0000 | Thrombosis and Haemostasis, Schattauer

Functional responses of bone cells to thrombin

Cells responsible for the formation and maintenance of bone express thrombin-responsive members of the protease-activated receptor family of G protein-coupled receptors...

Keywords: bone healing, intracellular calcium, osteoblast, osteoclast, phosphoinositol metabolism, prostaglandins, protease-activated receptor, thrombin

08/2006 | Biological Chemistry, Walter de Gruyter

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Items for "thrombin"