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Items for "tau"

Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau and is accompanied by abnormal behavior in mice

Calcineurin is a Ca2+/calmodulin-dependent phosphatase that dephosphorylates numerous substrates in different neuronal compartments...

Keywords: activity, calcineurin, cyclosporin A, spatial memory, tau

07/2006 | Biological Chemistry, Walter de Gruyter
Variability in longitudinal cerebrospinal fluid tau and phosphorylated tau measurements

Background: The influence of assay variation and duration of storage on changes in cerebrospinal fluid (CSF) levels of tau and phosphorylated (P)-tau with time was evaluated in 112 patients with various neurological disorders.

Methods: These patients (aged 66±9 years, 52% male), referred to our memory clinic, underwent two spinal taps (mean interval 19 months) and the baseline samples were assayed twice in a sandwich enzyme-linked immunosorbent assay (ELISA): once after the first spinal tap (A1) and once in a separately stored aliquot (A2) simultaneous with the follow-up sample (B).

Results: Coefficients of variances (CVs) of tau and P-tau levels determined in repeated spinal taps (?B–A2) measured in one assay (10.9% and 7.6%) were lower (p<0.01) than the CVs observed in two different (?B–A1) assays (16.5% and 11.7%)...

Keywords: biomarker, cerebrospinal fluid, phosphorylated (P)-tau, tau

09/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter