Items for "targeted gene replacement"

Plasma levels of bradykinin are suppressed in factor XII-deficient mice

A genetically-transmissible factor (F) XII-inactivated allele has been produced in mice by targeted replacement of exons 38 of the FXII gene with the neomycin resistance gene...

Keywords: FXII deficiency, targeted gene replacement, bradykinin generation, vasoactivity, reproduction, intrinsic coagulation pathway, contact activation