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Items for "steroid hydroxylation"

Inhibition of aldosterone biosynthesis by staurosporine

Staurosporine (STS) is a very potent broad-range kinase inhibitor, and its antiproliferative properties made it a lead compound for protein kinase C (PKC) inhibitors with therapeutic potential...

Keywords: adrenodoxin, aldosterone, blood pressure, CYP11B2, cytochrome P450, protein kinase inhibitor, staurosporine, steroid hydroxylation

07/2005 | Biological Chemistry, Walter de Gruyter
Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria

Mitochondrial cytochrome P450 systems are an indispensable component of mammalian steroid biosynthesis; they catalyze regio- and stereo-specific steroid hydroxylations and consist of three protein entities: adrenodoxin reductase (AdR), adrenodoxin (Adx), and a mitochondrial cytochrome P450 enzyme, e.g., CYP11A1 (P450 side chain cleavage, P450scc)...

Keywords: adrenodoxin, Apoptosis, CYP11A1, cytochrome P450, electron transfer chain, mitochondria, reactive oxygen species, steroid hydroxylation

05/2005 | Biological Chemistry, Walter de Gruyter