Items for "statin treatment"

A1166C polymorphism of the angiotensin AT1 receptor (AT1R) gene alters endothelial response to statin treatment

Background: The function of vascular endothelium is influenced by several factors: low-density lipoprotein (LDL) cholesterol, oxidative stress and the reninangiotensin system.

Methods: We tested the hypothesis that polymorphisms A1166C of the angiotensin AT1 receptor (AT1R) gene, C242T and A640G of the pphox22 gene (p22 phox is an essential component of NADH/NADPH oxidases) and G894T of the endothelial nitric oxide (NO) synthase (eNOS) gene influence endothelial function and its reaction to statin treatment...

Keywords: genetic polymorphisms, statin treatment, vascular endothelium