Items for "spontaneous preterm birth"

?2-adrenergic receptor gene polymorphisms and pregnancy outcome

Aims: The association between alleles at two loci of the polymorphic ?2-adrenergic receptor (?2AR) gene and pregnancy outcome was determined.

Methods: In a case-control study, buccal swabs obtained from 159 mother-infant pairs after a preterm or term birth were analyzed by gene amplification and endonuclease digestion for polymorphisms at codons 16 and 27 of the ?2AR gene.

Results: Homozygosity for allele A at codon 16 (Arg-16) occurred in 26 (20.5%) of 127 mothers with a term birth and in none of the mothers who had a spontaneous preterm birth (p = 0.002)...

Keywords: ?2-adrenergic receptor, genetic polymorphism, pregnancy, spontaneous preterm birth