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Items for "splicing"

Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs

The biogenesis of spliceosomal small nuclear RNAs (snRNAs) involves organized translocations between the cytoplasm and certain nuclear domains, such as Cajal bodies and nucleoli...

Keywords: nucleolus, snRNA, snRNP, splicing

10/2006 | Biological Chemistry, Walter de Gruyter
Diversity of proteasomal missions: fine tuning of the immune response

The majority of cellular proteins are degraded by proteasomes within the ubiquitin-proteasome ATP-dependent degradation pathway...

Keywords: antigen, ?-interferon, MHC class I, Ntn hydrolase, splicing, ubiquitin

09/2007 | Biological Chemistry, Walter de Gruyter
Effect of bleomycin and cisplatin on the expression profile of SRA1, a novel member of pre-mRNA splicing factors, in HL-60 human promyelocytic leukemia cells

Recently, a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors, SRA1 (SR-A1), has been discovered and cloned from members of our group, whose gene was found to be overexpessed in a series of human tumors...

Keywords: anticancer drugs, Apoptosis, DNA laddering, MTT, RT-PCR, splicing

01/2007 | Biological Chemistry, Walter de Gruyter