The conversion of the ?-helical, cellular isoform of the prion protein (PrPC) to the insoluble, ?-sheet-rich, infectious, disease-causing isoform (PrPSc) is the fundamental event in the prion diseases...
Keywords: ?-helix, amyloid, ?-sheet transition states, cellular prion protein (PrP), sodium dodecylsulfate
06/2005 | Biological Chemistry, Walter de Gruyter