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Items for "smooth muscle cells"

Modulation of protease nexin-1 activity by polysaccharides

Protease nexin-1 (PN-1) is a non-circulating pericellular serpin expressed by vascular cells. PN-1 inhibits different proteases but when associated with glycosaminoglycans, its activity is mainly directed towards thrombin...

Keywords: Protease nexin-1, thrombin, smooth muscle cells, polysaccharides, fucoidans

00/0000 | Thrombosis and Haemostasis, Schattauer
Interleukin-4 differentially regulates osteoprotegerin expression and induces calcification in vascular smooth muscle cells

Vascular calcification is characterized by cellular transdifferentiation and expression of bone-related matrix proteins that result in the presence of bone-like structures in the vascular wall...

Keywords: Cbfa1, interleukin-4, osteoprotegerin, smooth muscle cells, vascular calcification

04/2006 | Thrombosis and Haemostasis, Schattauer
Dual antagonists of the bradykinin B1 and B2 receptors based on a postulated common pharmacophore from existing non-peptide antagonists

We have recently drawn attention to the fact that most non-peptide antagonists of the kinin B1 receptor reported so far are structurally related, possessing the core motif phenyl-SO2-NR-(spacer2–4)-CO-NRR...

Keywords: bradyzide, LF16-0687, rabbit aorta, radioligand binding assay, smooth muscle cells

02/2006 | Biological Chemistry, Walter de Gruyter