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site-directed mutagenesis
Items for "site-directed mutagenesis"
Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase
Degradation of membrane-bound sphingomyelin to phosphorylcholine and ceramide is catalyzed by the water-soluble lysosomal acid sphingomyelinase (A-SMase)...
Keywords: acid sphingomyelinase, saposin-homologous domain, site-directed mutagenesis, water-lipid interface
12/2004 | Biological Chemistry, Walter de GruyterMolecular basis of the complex formation between the two calcium-binding proteins S100A8 (MRP8) and S100A9 (MRP14)
S100 proteins form characteristic homo- and/or heterodimers that play a role in calcium-mediated signaling...
Keywords: heterodimerization, homodimerization, myeloid related proteins (MRP), site-directed mutagenesis, S100 proteins, yeast two-hybrid
05/2005 | Biological Chemistry, Walter de GruyterA role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin II AT1 receptor
Several studies have proposed that angiotensin II (Ang II) binds to its receptor AT1 through interactions with residues in helices V and VI, suggesting that the distance between these helices is crucial for ligand binding...
Keywords: dimerization, folding, GPCR, maturation, site-directed mutagenesis
03/2006 | Biological Chemistry, Walter de GruyterGlutamic acid-141: a heme ‘bodyguard’ in anionic tobacco peroxidase
The role of the conserved glutamic acid residue in anionic plant peroxidases with regard to substrate specificity and stability was examined...
Keywords: expression, purification, radiation-induced inactivation, recombinant tobacco peroxidase, refolding, site-directed mutagenesis, substrate specificity
04/2007 | Biological Chemistry, Walter de GruyterLumazine proteins from photobacteria : localization of the single ligand binding site to the N-terminal domain
Lumazine protein is believed to serve as an optical transponder in bioluminescence emission by certain marine bacteria...
Keywords: lumazine proteins, nuclear magnetic resonance (NMR) spectroscopy, photobacteria, Photobacterium leiognathi, riboflavin synthase, site-directed mutagenesis
12/2007 | Biological Chemistry, Walter de GruyterStepwise synthesis of chitooligosaccharides through a transition-state analogue substrate catalyzed by mutants of chitinase A1 from Bacillus circulans WL-12
Several mutants of chitinase A1 from
Keywords: Bacillus circulans WL-12, chitinase A1, one-pot synthesis, site-directed mutagenesis, sugar oxazoline, transition-state analog substrate, transglycosylation
08/2006 | Holzforschung, Walter de GruyterReconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
Azurocidin belongs to the serprocidin family, but it is devoid of proteolytic activity due to a substitution of His and Ser residues in the catalytic triad...
Keywords: azurocidin, catalytic triad, insect cell expression system, proteolytic activity, site-directed mutagenesis
07/2008 | Biological Chemistry, Walter de GruyterContribution of the C30/C75 disulfide bond to the biological properties of onconase
Onconase, a member of the pancreatic type ribonuclease family, is currently used as a chemotherapeutic agent for the treatment of different types of cancer...
Keywords: catalytic activity, cytotoxicity, ribonuclease inhibitor evasion, site-directed mutagenesis, stability
08/2008 | Biological Chemistry, Walter de GruyterFunctional tyrosine residue in the active center of human dipeptidyl peptidase III
Human dipeptidyl peptidase III (DPP III) is a member of the metallopeptidase family M49 with an implied role in the pain-modulatory system and endogenous defense against oxidative stress...
Keywords: aminopeptidase, peptidase family M49, site-directed mutagenesis
02/2008 | Biological Chemistry, Walter de Gruyter