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Items for "single nucleotide polymorphisms (SNPs)"

The uncoupling protein-1 gene ?3826A/G polymorphism and hypertension in Japanese subjects

Background: The possible effects of the uncoupling protein-1 (UCP-1) gene ?3826A/G polymorphism on hypertension (HT) have yet to be elucidated.

Methods: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the ?3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.

Results: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs...

Keywords: blood pressure, elderly, gender, hypertension, single nucleotide polymorphisms (SNPs)

09/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
A rapid and accurate approach to identify single nucleotide polymorphisms of mitochondrial DNA using MALDI-TOF mass spectrometry

Background: Single nucleotide polymorphisms (SNPs) of mitochondrial DNA (mtDNA) are involved in physiological and pathological conditions...

Keywords: high-throughput analysis, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), mitochondrial DNA (mtDNA), multiplex assay, single nucleotide polymorphisms (SNPs), uniplex assay

03/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter