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signal transduction
Items for "signal transduction"
Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of Gq, PLC-, IP3 and 5,6-epoxyeicosatrienoic acid
The acute physiologic release of tissue-type plasminogen activator (t-PA) from the endothelium is critical for vascular homeostasis...
Keywords: Tissue-type plasminogen activator, signal transduction, pharmacology, thrombin, protease-activated receptor, epoxyeicosatrienoic acids (EET’s)
00/0000 | Thrombosis and Haemostasis, SchattauerResolution of inflammation: Intracellular feedback loops in the endothelium
Timely termination of the inflammatory reaction is equally important as its elicitation, since a persistent or exaggerated response may lead to detrimental effects in the affected tissues and organs...
Keywords: Endothelial cells, signal transduction, inflammation
03/2007 | Thrombosis and Haemostasis, SchattauerUbiquitylation within signaling pathways in- and outside of inflammation
Ubiquitin is a highly conserved 76-amino-acid peptide that becomes covalently attached to lysine residues of target proteins...
Keywords: Endothelial cells, signal transduction, inflammation
03/2007 | Thrombosis and Haemostasis, SchattauerFluorescent proteins and fluorescence resonance energy transfer (FRET) as tools in signaling research
The advent of fluorescent proteins has revolutionized signaling research, shifting focus from biochemical assays to analysis of live cells, organized tissues and even entire organisms...
Keywords: Endothelial cells, signal transduction, protein trafficking
03/2007 | Thrombosis and Haemostasis, SchattauerOncogenic Ras in tumour progression and metastasis
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Keywords: extracellular signal-regulated kinase (ERK), Migration, phosphatidylinositol 3-kinase (PI3-K), Rho GTPases, signal transduction, transformation
03/2005 | Biological Chemistry, Walter de GruyterPhosphoinositide 3-kinase signaling in the cellular response to oxidative stress
Oxidative stress is linked to the pathogenesis and pathobiochemistry of various diseases, including cancer, diabetes and cardiovascular disorders...
Keywords: AKT, FoxO-proteins, oxidant signaling, oxidative stress, phosphoinositide 3?-kinase (PI 3-kinase), protein kinase B, signal transduction
03/2005 | Biological Chemistry, Walter de GruyterDoxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells
Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC)...
Keywords: connexin-43, extracellular signal-regulated kinase (ERK), gap junction, mitogen-activated protein (MAP) kinase, oxidative stress, signal transduction, stress signaling
03/2005 | Biological Chemistry, Walter de GruyterTGF?-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4
Advanced malignancies often exhibit increased concentrations of transforming growth factor-? (TGF?), which has been suggested to promote invasion and metastasis...
Keywords: epithelial dedifferentiation, extracellular signal-regulated kinase (ERK), focal complex formation, Rho-GTPases, signal transduction, transforming growth factor-? (TGF?)
03/2005 | Biological Chemistry, Walter de GruyterCholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinases
Elevated low-density lipoprotein (LDL) levels induce activation of the p38 mitogen-activated protein kinase (MAPK), a stress-activated protein kinase potentially participating in the development of atherosclerosis...
Keywords: cholesterol, HDL, LDL, lipoproteins, p38 MAPK, signal transduction
09/2005 | Biological Chemistry, Walter de GruyterDual signal transduction mediated by a single type of olfactory receptor expressed in a heterologous system
Controversy exists over the relationship between the cAMP and IP3 pathways in vertebrate olfactory signal transduction, as this process is known to occur by either of the two pathways...
Keywords: cAMP pathway, HEK-293, IP3 pathway, odorant, olfactory receptor I7, signal transduction
01/2006 | Biological Chemistry, Walter de GruyterHypoxia and lipid signaling
Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues...
Keywords: eicosanoids, Gene expression, hypoxia, hypoxia-inducible factor, signal transduction, sphingolipids
10/2006 | Biological Chemistry, Walter de GruyterSinglet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine
Singlet oxygen (1O2), an electronically excited form of molecular oxygen, is a mediator of biological effects of ultraviolet A radiation, stimulating signaling cascades in human cells...
Keywords: oxidative stress, photosensitization, signal transduction, tyrosine phosphorylation, ultraviolet radiation
10/2006 | Biological Chemistry, Walter de GruyterProteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more
Serine proteinases, like trypsin, can play a hormone-like role by triggering signal transduction pathways in target cells...
Keywords: hormone action, inflammation, kallikreins, protease-activated receptors, proteases, proteinases, receptors, signal transduction, trypsin
06/2006 | Biological Chemistry, Walter de GruyterKallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs)
We tested the hypothesis that human tissue kallikreins (hKs) may regulate signal transduction by cleaving and activating proteinase-activated receptors (PARs)...
Keywords: inflammation, kallikreins, receptors, serine proteinases, signal transduction, trypsin
06/2006 | Biological Chemistry, Walter de GruyterInvolvement of Kupffer cell-dependent signaling in T3-induced hepatocyte proliferation in vivo
Thyroid hormone-induced calorigenesis triggers liver oxidative stress with concomitant TNF-α production by Kupffer cells and up-regulation of gene expression...
Keywords: cell proliferation, signal transduction
01/2007 | Biological Chemistry, Walter de Gruyter