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Items for "serine proteases"

Anti-metastatic effects of serine protease inhibitors: animal models for analysis

To date, no effective adjuvant drug preventing the aggressive spread of tumour cells in late stages of cancer disease or at the time-point of primary tumour removal is available...

Keywords: Tiermodelle, Serinproteasen, Proteaseinhibitoren, Metastasierung, Screening, Lymphom, Fibrosarkom

01/2007 | Hämostaseologie, Schattauer
The kallikrein world: an update on the human tissue kallikreins

Human tissue kallikreins (hKs) are attracting increased attention owing to their association with various forms of cancer and other diseases...

Keywords: Cancer, clinical applications, proteolytic cascade, regulation, serine proteases

06/2006 | Biological Chemistry, Walter de Gruyter
Cellular distribution of human tissue kallikreins: immunohistochemical localization

We have studied the immunohistochemical expression (IE) of eight non-tissue-specific human kallikreins (hKs) (hK5, 6, 7, 10, 11, 12, 13, and 14) in different normal tissues...

Keywords: cancer biomarkers, human tissue kallikreins, immunohistochemistry, prognostic markers, serine proteases

06/2006 | Biological Chemistry, Walter de Gruyter
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies

Human tissue kallikreins (genes, KLKs; proteins, hKs) are a subgroup of hormonally regulated serine proteases...

Keywords: antibody generation, cancer biomarkers, human tissue kallikreins, protein expression, protein purification, serine proteases

06/2006 | Biological Chemistry, Walter de Gruyter
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy

Kallikrein 11 (KLK11, TLSP, hippostatin) is a member of the human kallikrein gene family, which includes PSA, KLK2 and 12 other members, all localized on chromosome 19q13.4...

Keywords: free PSA, kallikreins, PCR, prostate, prostate cancer, prostate-specific antigen, PSA, serine proteases, tumor biomarkers

06/2006 | Biological Chemistry, Walter de Gruyter
Helicobacter pylori-induced downregulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases

The secretory leukocyte protease inhibitor (SLPI) exerts antiproteolytic activity towards serine proteases, as well as anti-microbial and anti-inflammatory effects...

Keywords: elastase, gastric cell lines, H. pylori infection, serine proteases, SLPI

07/2006 | Biological Chemistry, Walter de Gruyter
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)

Human kallikrein-related peptidase 12 (KLK12) is a new member of the human tissue kallikrein family...

Keywords: enzyme activity, enzyme cascades, serine proteases, tissue kallikreins, trypsin-like activity, tumor markers

04/2007 | Biological Chemistry, Walter de Gruyter