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Items for "serine protease inhibitor"

Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin

A number of serine, cysteine, metallo- and acid proteases were evaluated for their ability to proteolytically cleave the serine protease inhibitor trappin-2, also known as pre-elafin, and to release elafin from its precursor...

Keywords: elafin, proteolytic processing, serine protease inhibitor, trappin-2, tryptase

04/2005 | Biological Chemistry, Walter de Gruyter
Increased local levels of granulocyte colony-stimulating factor are associated with the beneficial effect of pre-elafin (SKALP/trappin-2/WAP3) in experimental emphysema

Few therapeutic options are offered to treat inflammation and alveolar wall destruction in emphysema...

Keywords: chronic obstructive pulmonary disease (COPD), inflammation, lung, serine protease inhibitor

07/2006 | Biological Chemistry, Walter de Gruyter