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Items for "serine protease"

Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?

The kallikrein-related peptidase (KLK) gene family of 15 serine proteases encodes many proteins, including prostate specific antigen (PSA or KLK3), that are well described and/or are potential biomarkers for hormone-related cancers...

Keywords: mRNA splicing, nuclear localisation, serine protease, Transcriptome

06/2006 | Biological Chemistry, Walter de Gruyter
Activation and enzymatic characterization of recombinant human kallikrein 8

Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease...

Keywords: cancer biomarkers, human kallikrein 8, human kallikreins, kcat/Km, lysyl endopeptidase, serine protease

06/2006 | Biological Chemistry, Walter de Gruyter
Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins

Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...

Keywords: cancer metastasis, extracellular matrix, human kallikrein 4, ovarian cancer, prognostic markers, prostate cancer, serine protease, serine protease inhibitors

06/2006 | Biological Chemistry, Walter de Gruyter
Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues

Only one transcript for KLK10 was identified by RT-PCR in lung tissue, whereas KLK11 expressed at least four alternative transcripts...

Keywords: bronchus, Lung Cancer, real-time PCR, serine protease, tissue kallikrein-related protein

06/2006 | Biological Chemistry, Walter de Gruyter
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells

The human tissue kallikrein family of serine proteases (hK1–hK15 encoded by the genes KLK1KLK15) is involved in several cancer-related processes...

Keywords: nude mice, ovarian cancer, serine protease, tumor invasion

06/2006 | Biological Chemistry, Walter de Gruyter
Human kallikrein 10, a predictive marker for breast cancer

Our laboratory is involved in identifying genes that can be used as early diagnostic or prognostic markers in breast cancer...

Keywords: breast cancer, hK10, hypermethylation, kallikreins, predictive markers, serine protease

06/2006 | Biological Chemistry, Walter de Gruyter
Pathophysiology and diagnostic value of urinary trypsin inhibitors

Inflammation is an important indicator of tissue injury. In the acute form, there is usually accumulation of fluids and plasma components in the affected tissues...

Keywords: antiprotease, autoimmune disease, bikunin, C-reactive protein, chondroitin sulfate, elastase, infection, inflammation, inter-?-inhibitor, pro-enzyme, proteolytic enzyme, protease-activated receptor, serine protease, urinary trypsin inhibitor

01/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter