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Items for "sepsis"

Differential expression of tissue factor mRNA and protein expression in murine sepsis. The role of the granulocyte revisited

Tissue factor (TF) is a transmembrane protein, which is essential for initiation of the coagulation cascade...

Keywords: Tissue factor, Coagulation, sepsis, inflammation, granulocytes

00/0000 | Thrombosis and Haemostasis, Schattauer

Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock

Treatment of hemodynamic instability in septic shock often demands the administration of vasopressor agents, although these may have deleterious effects on microcirculatory homeostasis...

Keywords: sepsis, iNOS, EMPHO, 1400W, L-NMMA, norepinephrine

04/2006 | Thrombosis and Haemostasis, Schattauer

Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells

Sepsis is characterized by a concurrent activation of inflammation and coagulation. Recently, recombinant human activated protein C was shown to decrease mortality in patients with severe sepsis presumably due to a combined anti-inflammatory and anticoagulant effect...

Keywords: Tissue factor, ethyl pyruvate, sepsis, lipopolysaccharide, THP-1 monocytic cells

12/2006 | Thrombosis and Haemostasis, Schattauer

Coagulation and endothelial dysfunction during longterm hyperdynamic porcine bacteremia effects of selective inducible nitric oxide synthase inhibition

Coagulation abnormalities have been implicated in the pathogenesis of sepsis and organ dysfunction. Nitric oxide (NO) is regarded as a critical mediator of many vascular pathologies, including sepsis...

Keywords: Coagulation, DIC, nitric oxide, oxidative stress, sepsis

00/0000 | Thrombosis and Haemostasis, Schattauer

Plasma endothelin-1 and clinical manifestations of neonatal sepsis

Aim: To determine whether plasma endothelin-1 (ET-1) relates to clinical manifestations of sepsis in the newborn, especially with systemic hypotension, acidosis, severe hypoxemia (which may represent pulmonary hypertension) and oliguria.

Methods: Prospective study of 35 consecutive newborns with clinical sepsis: 22 with hemoculture-positive (HC+) sepsis and 13 hemoculture-negative (HC–)...

Keywords: endothelin-1, hypoxemia, Newborn, oliguria, pulmonary hypertension, sepsis, seizures, SNAP-II, systemic hypotension

11/2004 | Journal of Perinatal Medicine, Walter de Gruyter

Ranitidine and late-onset sepsis in the neonatal intensive care unit

Aims: The objective of the study was to examine the effect of ranitidine on the incidence of late onset sepsis.

Methods: This study was based on information extracted from charts of 569 infants admitted to the neonatal intensive care unit (NICU) from July 2003 to July 2005...

Keywords: Bacteremia, histamine 2 antagonist, Neonatal intensive care unit, nosocomial infections, premature infant, ranitidine, sepsis

04/2007 | Journal of Perinatal Medicine, Walter de Gruyter

Einfluss der verzögerten Transportdauer bei Raumtemperatur auf die Rate der falsch negativen Blutkulturen im BACTEC? 9000 Gerät. Impact of delayed entry at room temperature on the rate of false negative blood cultures with the BACTEC? 9000 instrument

One hospital-based laboratory and one laboratory serving a number of hospitals prospectively studied 3.907 blood culture bottles of the BACTEC? 9000 System (BD Diagnostics, Heidelberg, Germany) (1.888 aerobic bottles, 1.880 anaerobic bottles and 139 pediatric bottles)...

Keywords: BACTEC? 9000, blood culture diagnostic, septicemia

04/2005 | LaboratoriumsMedizin, Walter de Gruyter

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