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Items for "selective substrate"

Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L

The S1 and S2 subsite specificity of recombinant human cathepsins X was studied using fluorescence resonance energy transfer (FRET) peptides with the general sequences Abz-Phe-Xaa-Lys(Dnp)-OH and Abz-Xaa-Arg-Lys(Dnp)-OH, respectively (Abz=ortho-aminobenzoic acid and Dnp=2,4-dinitrophenyl; Xaa=various amino acids)...

Keywords: carboxymonopeptidase, cathepsin B, cathepsin L, cathepsin X, lysosomal cathepsins, selective substrate, specificity studies

11/2005 | Biological Chemistry, Walter de Gruyter
A new selective substrate for cathepsin E based on the cleavage site sequence of ?2-macroglobulin

Cathepsin E is an intracellular aspartic proteinase of the pepsin family predominantly expressed in cells of the immune system and believed to contribute to homeostasis by participating in host defense mechanisms...

Keywords: aspartic proteinase, ?2-macroglobulin, cathepsin E, selective substrate

03/2005 | Biological Chemistry, Walter de Gruyter