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Items for "scrapie"

Cellular prion protein acquires resistance to proteolytic degradation following copper ion binding

The conversion of cellular prion protein (PrPC) into its pathological isoform (PrPSc) conveys an increase in hydrophobicity and induces a partial resistance to proteinase K (PK)...

Keywords: BSE, prion protein, proteinase K, proteolysis, scrapie

08/2004 | Biological Chemistry, Walter de Gruyter
The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of ?-linked polyglucose

An inert polysaccharide scaffold identified as a 5–15% component of prion rods (PrP 27–30) is unambiguously distinguishable from the N-glycosyl groups and the GPI anchor of PrP, and consists predominantly of 1,4-linked glucose with some branching via 1,4,6-linked glucose...

Keywords: amyloid, corpora amylacea, glycogen, prion, scrapie, V-helix

11/2005 | Biological Chemistry, Walter de Gruyter
Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion

A characteristic feature of prion diseases such as bovine spongiform encephalopathy (BSE) is the accumulation of a pathological isoform of the host-encoded prion protein, PrP...

Keywords: BSE diagnosis, 2D-FIDA, fluorescence correlation spectroscopy, prion, proteinase, scrapie, single particle detection

01/2006 | Biological Chemistry, Walter de Gruyter