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Items for "sample size"

A Computer Program to Estimate Power and Relative Efficiency of Flexibly Matched Case-control Studies

Objectives: We recently introduced the concept of flexible matching strategies with varying proportions of a dichotomous matching factor among controls to increase power and efficiency of case-control studies...

Keywords: Case-control studies, confidence intervals, efficiency, epidemiologic methods, Research design, sample size

01/2005 | Methods of Information in Medicine, Schattauer
Quantification of relative changes in specific mRNAs from frozen whole blood – methodological considerations and clinical implications

Background: Based on quantification of relative changes in lipopolysaccharide (LPS)-regulated mRNA transcripts, the present study aimed to establish a robotic method to isolate RNA from stabilized frozen whole blood suitable for gene expression analysis.

Methods: Whole blood (±LPS) was stored in EasyLyse? solution or PAXgene® tubes (room temperature and ?70°C) for comparison of storage methods, then subjected to robotic isolation of total RNA...

Keywords: frozen whole blood, Gene expression, globin mRNA, PAXgene®, Quality Control, sample size

02/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter