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A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - Part I: Pharmacological characterization
We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC 50 of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidases, such as CPN, CPZ and CPD, and 5- and 12-fold selectivity against CPE (CPH) and CPB, respectively...
Keywords: TAFI, carboxypeptidases, potency, selectivity, safety, pharmacokinetics
01/2007 | Thrombosis and Haemostasis, SchattauerThe Safety and Quality of Decision Support Systems
Objectives: The use of clinical decision support systems (CDSS) can improve the overall safety and quality of health care delivery, but may also introduce machine-related errors...
Keywords: Decision Support Systems, safety, error, automation bias, electronic prescribing
01/2006 | Methods of Information in Medicine, SchattauerPharmacy-based laboratory services: past or future and risk or opportunity?
Laboratory diagnostics has undergone relevant changes in organization and complexity, providing new opportunities and risks...
Keywords: laboratory diagnostics, pharmacy, point-of-care testing, risk, safety
04/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter