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Items for "S-adenosyl-l-methionine"

Structural and functional comparison of HemN to other radical SAM enzymes

Radical SAM enzymes have only recently been recognized as an ancient family sharing an unusual radical-based reaction mechanism...

Keywords: BioB, [4Fe-4S] cluster, HemN, littorine mutase, MoaA, radical SAM enzymes, S-adenosyl-l-methionine

10/2005 | Biological Chemistry, Walter de Gruyter

Functional analysis of amino acid residues at the dimerisation interface of KpnI DNA methyltransferase

KpnI DNA-(N⁶-adenine) methyltransferase (M.KpnI) recognises the sequence 5?-GGTACC-3? and transfers the methyl group from S-adenosyl-L-methionine (AdoMet) to the N6 position of the adenine residue in each strand...

Keywords: DNA methyltransferase, KpnI DNA methyltransferase, S-adenosyl-l-methionine, target recognition domain

05/2006 | Biological Chemistry, Walter de Gruyter

Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy

Aim: To compare the efficacy of the ursodeoxycholic acid (UDCA) and S-adenosyl-L-methionine (SAMe) monotherapy with their combined effect on intrahepatic cholestasis of pregnancy (ICP).

Patients and methods: We studied singleton pregnancies at <36 weeks with a moderate or severe form of ICP between January 1999 and March 2004...

Keywords: Intrahepatic cholestasis of pregnancy, S-adenosyl-l-methionine, ursodeoxycholic acid

10/2006 | Journal of Perinatal Medicine, Walter de Gruyter

Differential methylation kinetics of individual target site strands by T4Dam DNA methyltransferase

Prokaryote DNA methyltransferases (MTases) of the Dam family (including those of bacteriophages T2 and T4) catalyze methyl group transfer from S-adenosyl-L-methionine (AdoMet), producing S-adenosyl-L-homocysteine (AdoHcy) and methylated adenine residues in palindromic GATC sequences...

Keywords: hemimethylation, pre-steady-state methylation, reaction burst, S-adenosyl-L-homocysteine, S-adenosyl-l-methionine