Items for "RNA interference"

Successful silencing of plasminogen activator inhibitor-1 in human vascular endothelial cells using small interfering RNA

Clinical as well as experimental evidence suggests that vascular overexpression of plasminogen activator inhibitor (PAI)-1, the primary physiological inhibitor of both urokinase and tissuetype plasminogen activator, may be involved in the pathophysiology of atherosclerosis and cardiovascular disease...

Keywords: Cell adhesion, fibrinolysis, Endothelial cells, plasminogen activator inhibitor-1, RNA interference