A novel chemo-genetic approach for the analysis of general acid-base catalysis by nucleobases in ribozymes is reviewed...
Keywords: chemo-genetics, general acid-base catalysis, nucleobases, RNA catalysis
07/2007 | Biological Chemistry, Walter de GruyterThe HDV ribozyme is an RNA enzyme from the human pathogenic hepatitis delta virus (HDV) that has recently also been identified in the human genome...
Keywords: gene therapy applications, global folding, RNA catalysis, terbium(III) footprinting, time-resolved FRET
07/2007 | Biological Chemistry, Walter de Gruyter