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Items for "ribosome"

Detecting Specific Ligand Binding to Nucleic Acids: A Test for Ultrasoft Laser Mass Spectrometry

Results from a new laser based mass spectrometry method termed LILBID (laser induced liquid bead ion desorption) are presented, which demonstrate the potential for the soft mass analysis of nucleic acids and their specific complexes in solution...

Keywords: LILBID laser mass spectrometry, DNA/RNA ligands, specific complexes, minor groove binders, ribosome

05/2007 | Zeitschrift für Physikalische Chemie, Oldenbourg Wissenschaftsverlag

Species-specific antibiotic-ribosome interactions: implications for drug development

In the cell, the protein synthetic machinery is a highly complex apparatus that offers many potential sites for functional interference and therefore represents a major target for antibiotics...

Keywords: antibiotics, Drug, lincomycin, macrolides, protein synthesis, ribosome, streptogramin

12/2005 | Biological Chemistry, Walter de Gruyter

Importance of tRNA interactions with 23S rRNA for peptide bond formation on the ribosome: studies with substrate analogs

The major enzymatic activity of the ribosome is the catalysis of peptide bond formation...

Keywords: peptide bond formation, puromycin, ribosome, tRNA

07/2007 | Biological Chemistry, Walter de Gruyter

Towards understanding selenocysteine incorporation into bacterial proteins

In bacteria, UGA stop codons can be recoded to direct the incorporation of selenocysteine into proteins on the ribosome...

Keywords: electron cryomicroscopy, Fluorescence, protein synthesis, recoding, ribosome, selenocysteine

10/2007 | Biological Chemistry, Walter de Gruyter

Fast in vitro translation system immobilized on a surface via specific biotinylation of the ribosome

The ribosome is the macromolecular machine responsible for translating the genetic code into polypeptide chains...

Keywords: elongation factor, ribosome, single-molecule fluorescence spectroscopy, surface immobilization, surface plasmon resonance, translation

09/2008 | Biological Chemistry, Walter de Gruyter