The sizable symmetrical region, comprising 180 ribosomal RNA nucleotides, which has been identified in and around the peptidyl transferase center (PTC) in crystal structures of eubacterial and archaeal large ribosomal subunits, indicates its universality, confirms that the ribosome is a ribozyme and evokes the suggestion that the PTC evolved by gene fusion...
Keywords: peptide bond formation, ribosome structure and function, ribosomal symmetrical region, rotatory mechanism
09/2005 | Biological Chemistry, Walter de Gruyter