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Items for "rheumatoid arthritis"

Bone scintigraphy and clinical outcome in rheumatoid gonarthritis

AIM: For evaluation of the effect of radiosynoviorthesis (RSO) on the early and delayed uptake of 99mTc-biphosphonates and its relation to clinical outcome we studied these variables before and after radiosynoviorthesis performed on 41 knees affected by rheumatoid arthritis. METHOD: Thirty-seven patients with rheumatoid gonarthritis were treated by intraarticular injection with 185 MBq yttrium-90 citrate...

Keywords: 3-Phasen-Skelettszintigraphie, Radiosynoviorthese

01/2003 | Nuklearmedizin, Schattauer
Multicenter study of radiosynoviorthesis: Clinical outcome in osteoarthritis and other disorders with concomitant synovitis in comparison with rheumatoid arthritis

Aim: Evaluation of the effectiveness of radiosynoviorthesis (RSO) in osteoarthritis and other disorders with concomitant synovitis versus rheumatoid arthritis by means of a standardized questionnaire...

Keywords: Radiosynoviorthese, aktivierte Arthrose, Synovialitis, Arthritis, rheumatoide Arthritis

01/2004 | Nuklearmedizin, Schattauer
Diagnosis of initial changes in patients suffering from rheumatoid arthritis. Two years follow up control with a low-field magnetic resonance scanner, 3-phase bone scintigraphy and conventional x-ray

Besides conventional x-ray, in the diagnostic work up of initial changes in patients suffering from rheumatoid arthritis (RA), 3-phase bone scintigraphy (3P-Sz) is as well established as magnetic resonance imaging (MRI)...

Keywords: rheumatoide Arthritis, 3-Phasen-Skelettszintigraphie, Niederfeld-Magnetresonanztomographie, Projektionsradiographie

01/2004 | Nuklearmedizin, Schattauer
Disease modifying treatment for feline rheumatoid arthritis

Feline erosive polyarthritis includes the more common periosteal proliferative polyarthritis (PPP) and the rarely seen rheumatoid arthritis (RA) (11)...

Keywords: Disease modifying therapy, cats, rheumatoid arthritis

05/2005 | Veterinary and Comparative Orthopaedics and Traumatology, Schattauer
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S

Rheumatoid arthritis is an inflammatory and disabling joint disease affecting 0.5–1.5% of the population...

Keywords: cathepsin K, cathepsin S, cysteine protease inhibitor, gold, rheumatoid arthritis

03/2007 | Biological Chemistry, Walter de Gruyter
Changes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the serum of patients with autoimmune diseases: association with age and disease activity

Matrix metalloproteinases participate in the degradation of the extracellular matrix proteins and are regulated mainly by their respective tissue inhibitors...

Keywords: ageing, enzymes, Osteoarthritis, rheumatoid arthritis

08/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Efficacy of three ELISA measurements of anti-cyclic citrullinated peptide antibodies in the early diagnosis of rheumatoid arthritis

The objective of the present study was to determine the efficacy of anti-cyclic citrullinated peptide (anti-CCP) antibody detection in the early diagnosis of rheumatoid arthritis (RA), as well as to compare three commercially available enzyme-linked immunosorbent assay (ELISA) kits used to detect such antibodies...

Keywords: anti-cyclic citrullinated peptide antibodies, diagnosis, rheumatoid arthritis, rheumatoid factor

11/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Sensitive immunoassays for the autoantibodies reacting against citrullinated carboxy-terminal telopeptides of type I and type II collagens in patients with rheumatoid arthritis

We developed sensitive assay methods for autoantibodies recognizing the citrullinated synthetic peptides derived from type I and type II collagens in patients with rheumatoid arthritis (RA)...

Keywords: autoantibodies, citrullination, collagen, rheumatoid arthritis, telopeptide

12/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Diagnosis and prognosis of early rheumatoid arthritis, with special emphasis on laboratory analysis

Diagnosis of rheumatoid arthritis (RA) is mainly based on clinical criteria of symmetric polyarthritis of the hands and feet, with morning stiffness lasting usually more than 1 h...

Keywords: arthritis, autoantibodies, cyclic citrullinated peptide, diagnosis, Prognosis, C-reactive protein, rheumatoid arthritis, rheumatoid factor

02/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Optimization of an enzymatic method for the determination of lysosomal N-acetyl-?-D-hexosaminidase and ?-glucuronidase in synovial fluid

Background: Our goal was to develop a suitably sensitive assay for N-acetyl-?-D-hexosaminidase (HEX) and ?-glucuronidase to allow their use as markers of joint diseases.

Methods: We optimized a spectrophotometric method for the determination of lysosomally derived HEX and ?-glucuronidase in synovial fluid on a microplate reader to improve its utility...

Keywords: ?-glucuronidase, Km, N-acetyl-?-D-hexosaminidase, rheumatoid arthritis, synovial fluid

08/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Antibodies to citrullinated peptides: a significant step forward in the early diagnosis of rheumatoid arthritis

The early diagnosis of rheumatoid arthritis (RA) has become a priority owing to the availability of effective disease-modifying agents that can improve patient wellbeing and influence the clinical outcome...

Keywords: anti-cyclic citrullinated peptide (CCP) antibodies, citrullinated peptides, filaggrin, rheumatoid arthritis

02/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Increased fructosamine in non-diabetic rheumatoid arthritis patients: role of lipid peroxides and glutathione

Modification of proteins by non-enzymatic glycation is one of the underlying factors known to play a major role in the pathogenesis of many clinical disorders...

Keywords: fructosamine, glutathione, malondialdehyde, rheumatoid arthritis

07/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Diagnostik und Prognostik der frühen rheumatoiden Arthritis unter besonderer Berücksichtigung der Labor-Analytik Diagnosis and prognosis of early rheumatoid arthritis, with special emphasis on laboratory analysis

Zusammenfassung

Ausgehend vom klinischen Befund einer Arthritis von zwei oder mehr Gelenken wird die Diagnose einer rheumatoiden Arthritis (RA) überwiegend nach klinischen kriterien gestellt; auch die Labordiagnostik trägt jedoch wesentlich zur Frühdiagnostik der RA bei, zum einen durch die Entzündungsdiagnostik, zum anderen durch den Nachweis der RA-typischen Autoantikörper Rheumafaktor und anti-CCP...

Keywords: arthritis, Autoantikörper, C-reaktives Protein, cyclisches citrulliniertes Peptid, Diagnose, Prognose, Rheumafaktor, rheumatoide Arthritis, autoantibodies, C-reactive protein, cyclic citrullinated peptide, diagnosis, Prognosis, rheumatoid arthritis, rheumatoid factor

08/2005 | LaboratoriumsMedizin, Walter de Gruyter
Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test in patients with recent-onset polyarthritis

Background: The high specificity of anti-cyclic citrullinated peptide antibodies (anti-CCP) helps substantially in the diagnosis of rheumatoid arthritis (RA), combined with classical markers such as rheumatoid factor (RF)...

Keywords: anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid arthritis, rheumatoid factor, third-generation anti-CCP ELISA

10/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Association of interleukin-1 genetic polymorphisms with the risk of rheumatoid arthritis in Chinese population

Background: Previous studies suggest that a variable number of tandem repeats polymorphism in the second intron of the interleukin-1 receptor antagonist gene and two single nucleotide polymorphisms at positions ?511 and +3954 of the interleukin-1? (IL-1B) gene are associated with an increased risk of autoimmune diseases...

Keywords: haplotype, interleukin-1?, interleukin-1 receptor antagonist, rheumatoid arthritis

08/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter