Items for "reference interval"

Partitioning reference values for several subpopulations using cluster analysis

Background: A crucial question when developing reference intervals is whether different subpopulations need their own reference interval or if a single joint reference interval can be used...

Keywords: cluster, partitioning, reference interval

Production of gender-specific morning salivary cortisol reference intervals using internationally accepted procedures

Background: Salivary cortisol concentrations correlate well with biologically active unbound free plasma cortisol concentrations...

Keywords: adrenal suppression, cortisol, reference interval, saliva, steroids

The effect of thyroid antibody positivity on reference intervals for thyroid stimulating hormone (TSH) and free thyroxine (FT₄) in an aged population

Our aims were: 1) to analyze the effect of the methodology used to derive clinically feasible cut-off values for thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb), which exhibit highly skewed distributions; and 2) to describe the influence of thyroid antibodies on thyroid stimulating hormone (TSH) and free thyroxine (FT₄) reference intervals among thyroid disease-free aged subjects...

Keywords: aged, hypothyroidism, reference interval, thyroid antibodies, thyroid function tests

Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)

Background: The National Academy of Clinical Biochemistry (NACB) stresses that the reference intervals for thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and thyroid stimulating hormone (TSH)-receptor antibodies (TRAb) should be based on young men who lack certain risk factors and have serum TSH between 0.5 and 2.0 mIU/L...

Keywords: composite distributions, ln-Gaussian distributions, models, NACB guidelines, rankit plot, reference interval, thyroid antibodies, thyroid hormones

Biochemical reference intervals for sex hormones with a new AutoDelfia method in aged men

Background: Our aim was to establish sex hormone reference intervals measured with a new AutoDelfia immunoassay method for aged men free of medication and/or conditions known to influence sex hormone levels.

Methods: The reference population consisted of 466 individuals between 64 and 97 years (mean 72 years) and a mean body mass index (BMI) of 26.9 kg/m².

Results and conclusions: Because age correlated significantly with most sex hormones studied, we calculated reference intervals for three age groups (64–69, 70–74 and ?75 years)...

Keywords: androgens, elderly, estrogens, men, reference interval, sex hormone-binding globulin

Distribution of plasma cardiac troponin I values in healthy subjects: pathophysiological considerations

Background: The aim of this study was to evaluate the distribution of cardiac troponin I (cTnI) values, measured by the ADVIA TnI-Ultra method (Siemens Medical Solutions Diagnostics SrL) in healthy subjects and to characterize its relation to gender, age, as well as to N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP).

Methods: A Caucasian population of 692 healthy subjects (311 males and 381 females) with a mean (SD) age of 45.3 (17.3) years [range 11–89 years; females 46.5 (17.3) years, males 43.8 (17.1) years] was enrolled...

Keywords: Acute coronary syndrome, age, cardiac troponin I (cTnI), gender, N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP), reference interval, troponin assay