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Items for "receptors"

Cross-talk of the renin-angiotensin and kallikrein-kinin systems

The renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems play a key role in multiple physiological and pathophysiological conditions, including growth and development, inflammation, blood pressure regulation and control of renal function...

Keywords: angiotensin, angiotensin-converting enzyme, development, kidney, kinins, receptors

02/2006 | Biological Chemistry, Walter de Gruyter

Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more

Serine proteinases, like trypsin, can play a hormone-like role by triggering signal transduction pathways in target cells...

Keywords: hormone action, inflammation, kallikreins, protease-activated receptors, proteases, proteinases, receptors, signal transduction, trypsin

06/2006 | Biological Chemistry, Walter de Gruyter

Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs)

We tested the hypothesis that human tissue kallikreins (hKs) may regulate signal transduction by cleaving and activating proteinase-activated receptors (PARs)...

Keywords: inflammation, kallikreins, receptors, serine proteinases, signal transduction, trypsin

06/2006 | Biological Chemistry, Walter de Gruyter

The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor

The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains...

Keywords: cytokines, Interleukin-6, NMR spectroscopy, protein structure, receptors