Signaling pathways based on the reversible phosphorylation of proteins control most aspects of cellular life in higher organisms...
Keywords: Cancer, ERK, hepatocytes, kinase, MEK, phosphatase, Raf, Ras, signaling
11/2005 | Biological Chemistry, Walter de GruyterDown-regulation of Ras signalling is mediated by specific GTPase-activating proteins (GAPs), which stimulate the very slow GTPase reaction of Ras by 105-fold...
Keywords: aluminium fluoride, beryllium fluoride, GTPase, GTPase-activating protein, neurofibromin, oncogene, Ras, transition state
09/2008 | Biological Chemistry, Walter de Gruyter