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Items for "PSA"

The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition

Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain...

Keywords: E-cadherin, EMT, KLK4, Migration, prostate cancer, PSA

06/2006 | Biological Chemistry, Walter de Gruyter

mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy

Kallikrein 11 (KLK11, TLSP, hippostatin) is a member of the human kallikrein gene family, which includes PSA, KLK2 and 12 other members, all localized on chromosome 19q13.4...

Keywords: free PSA, kallikreins, PCR, prostate, prostate cancer, prostate-specific antigen, PSA, serine proteases, tumor biomarkers

06/2006 | Biological Chemistry, Walter de Gruyter

Development of peptides specifically modulating the activity of KLK2 and KLK3

The prostate produces several proteases, the most abundant ones being kallikrein-related peptidase 3 (KLK3, PSA) and KLK2 (hK2), which are potential targets for tumor imaging and treatment...

Keywords: hK2, kallikrein, peptide modification, phage display, prostate cancer, PSA

06/2008 | Biological Chemistry, Walter de Gruyter

Gene expression changes associated with the anti-angiogenic activity of kallikrein-related peptidase 3 (KLK3) on human umbilical vein endothelial cells

Kallikrein-related peptidase 3 (KLK3, also known as prostate-specific antigen, PSA) is a chymotrypsin-like kallikrein that has anti-angiogenic properties...

Keywords: Angiogenesis, cell culture, microarray, prostate cancer, PSA