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Items for "prothrombin"

Increased plasma prothrombin concentration in cirrhotic patients with portal vein thrombosis and prothrombin G20210A mutation

It was the aim of the present study to investigate factor II levels in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) carrying the heterozygous G20210A prothrombin (PT) mutation...

Keywords: Liver cirrhosis, portal vein thrombosis, prothrombin

00/0000 | Thrombosis and Haemostasis, Schattauer

Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels

Elevated plasma prothrombin levels, due to the prothrombin 20210 G/A mutation or to acquired causes, are a risk factor for venous thrombosis, partly because of prothrombin-mediated inhibition of the protein C anticoagulant pathway and consequent activated protein C (APC) resistance...

Keywords: prothrombin, protein S, thrombin generation and APC resistance

00/0000 | Thrombosis and Haemostasis, Schattauer

Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation

The Scientific Committee of Molecular Biology Techniques (C-MBT) in Clinical Chemistry of the IFCC has initiated a joint project in co-operation with the European Commission, Joint Research Centre, Institute of Reference Materials and Measurements to develop and produce plasmid-type reference materials (RMs) for the analysis of the human prothrombin gene G20210A mutation...

Keywords: metrological traceability, molecular diagnostic testing, mutation, polymerase chain reaction, prothrombin, recombinant DNA, reference standards

08/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Certification of reference materials for detection of the human prothrombin gene G20210A sequence variant

Background: There is a need for reference materials (RMs) in the field of genetic testing for verification of test results obtained in patients and probands...

Keywords: molecular diagnostic testing, prothrombin, real-time polymerase chain reaction (PCR), reference material, sequence variant