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proteolysis
Items for "proteolysis"
High urokinase expression contributes to the angiogenic properties of endothelial cells derived from circulating progenitors
Endothelial progenitor cells (EPC) display a unique ability to repair vascular injury and promote neovascularization although the underlying molecular mechanisms remain poorly understood...
Keywords: Endothelial progenitor, urokinase, Angiogenesis, proteolysis
04/2006 | Thrombosis and Haemostasis, SchattauerPlasma prekallikrein/kallikrein processing by lysosomal cysteine proteases
Plasma kallikrein plays a role in coagulation, fibrinolysis and inflammation. Cathepsins B and L participate in (patho)physiological processes such as peptide antigen processing, tissue remodeling events, protein turnover in cells, hormone processing and tumor invasion...
Keywords: cathepsins, kallikrein, kinin system, proteolysis
11/2004 | Biological Chemistry, Walter de GruyterCellular prion protein acquires resistance to proteolytic degradation following copper ion binding
The conversion of cellular prion protein (PrPC) into its pathological isoform (PrPSc) conveys an increase in hydrophobicity and induces a partial resistance to proteinase K (PK)...
Keywords: BSE, prion protein, proteinase K, proteolysis, scrapie
08/2004 | Biological Chemistry, Walter de GruyterDegradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system
The sodium taurocholate cotransporting polypeptide (Ntcp, Slc10a1) is the major uptake system for bile acids into liver cells...
Keywords: aggresome, integral membrane proteins, N-linked glycosylation, proteasome, proteolysis, ubiquitin
10/2005 | Biological Chemistry, Walter de GruyterEvidence for a common regulation in the activation of a polyphenol oxidase by trypsin and sodium dodecyl sulfate
Polyphenol oxidase (PPO) was extracted from beet root, in both soluble and membrane fractions, and in both cases the enzyme was in a latent state...
Keywords: Beta vulgaris, betalains, latency, proteolysis, tyrosinase
06/2005 | Biological Chemistry, Walter de GruyterPlatelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma
Blood coagulation factor XII (FXII, Hageman factor) is a plasma serine protease which is autoactivated following contact with negatively charged surfaces in a reaction involving plasma kallikrein and high-molecular-weight kininogen (contact phase activation)...
Keywords: bradykinin, Coagulation, inflammation, kallikrein-kinin system, plasma proteins, proteolysis
02/2006 | Biological Chemistry, Walter de GruyterIdentification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19INK4d
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species...
Keywords: calpain, calpastatin, cyclin-dependent kinases, nuclear magnetic resonance spectroscopy, proteolysis, p19INK4d
03/2006 | Biological Chemistry, Walter de GruyterDistinctive functional features in prokaryotic and eukaryotic Cu,Zn superoxide dismutases
Bacterial and eukaryotic Cu,Zn superoxide dismutases show remarkable differences in the active site region and in their quaternary structure organization...
Keywords: conformational stability, Cu,ZnSOD, monomer-dimer equilibrium, peroxidative activity, proteolysis, quaternary structure
08/2004 | Biological Chemistry, Walter de GruyterRegulation of cathepsin K activity by hydrogen peroxide
Although cysteine cathepsins, including cathepsin K, are sensitive to oxidation, proteolytically active forms are found at inflammatory sites...
Keywords: cysteine cathepsin, inflammation, Oxidation, protease, proteolysis, sulfenic acid
08/2008 | Biological Chemistry, Walter de GruyterHuman monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and here, we examined
Keywords: cathepsin B, caveolin-1, co-culture, extracellular matrix, proteolysis
08/2008 | Biological Chemistry, Walter de GruyterCloning, expression and characterization of insulin-degrading enzyme from tomato (Solanum lycopersicum )
A cDNA encoding insulin-degrading enzyme (IDE) was cloned from tomato (
Keywords: insulinase, insulysin, metalloprotease, plant, proteolysis
01/2008 | Biological Chemistry, Walter de Gruyter