Items for "Protein sequence"

Hydrophobicity Analysis of Protein Primary Structures to Identify Helical Regions

OBJECTIVES: A wavelet based approach for the hydrophobicity analysis of protein primary structures is proposed to predict the presence of alpha helices in the secondary structure. METHODS: The information about hydropathy profile periodicity content together with a score of probability of occurrence of a single amino acid allows the localization of alpha helices. RESULTS: The accuracy is comparable to other consolidated predictors based on different techniques (i.e.: neural networks, hidden markov models). CONCLUSION: This method is particularly suitable to capture the amphiphilic character of the helical structures.

Keywords: Protein sequence, secondary structure, hydrophobicity, alpha helix, wavelet transform