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Items for "proteasome"

Thermoplasma acidophilum TAA43 is an archaeal member of the eukaryotic meiotic branch of AAA ATPases

Sequencing of the Thermoplasma acidophilum genome revealed a new gene, taa43, which codes for a 43-kDa protein containing one AAA domain; we therefore termed it Thermoplasma AAA ATPase of 43 kDa (TAA43)...

Keywords: Archaea, proteasome activating nucleotidase, proteasome, VAT, VAT2

11/2004 | Biological Chemistry, Walter de Gruyter

Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system

The sodium taurocholate cotransporting polypeptide (Ntcp, Slc10a1) is the major uptake system for bile acids into liver cells...

Keywords: aggresome, integral membrane proteins, N-linked glycosylation, proteasome, proteolysis, ubiquitin

10/2005 | Biological Chemistry, Walter de Gruyter

Protein oxidation and proteolysis

One of the hallmarks of chronic or severe oxidative stress is the accumulation of oxidized proteins, which tend to form high-molecular-weight aggregates...

Keywords: oxidative stress, PARP, proteasome, protein oxidation, ubiquitination

10/2006 | Biological Chemistry, Walter de Gruyter

Impact of the N-terminal amino acid on targeted protein degradation

The N-terminus of any protein may be used as a destabilization signal for targeted protein degradation...

Keywords: aminopeptidase, co-translational, deformylase, leucine, Methionine, proteasome, protein, ubiquitin

07/2006 | Biological Chemistry, Walter de Gruyter

Binding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis

Aflatoxins (AF) are contaminants of improperly stored foods; they are potent genotoxic and carcinogenic compounds, exerting their effects through damage to DNA...

Keywords: aflatoxin, Apoptosis, HepG2, oxidative stress, proteasome, proteolytic activity

01/2007 | Biological Chemistry, Walter de Gruyter

Regulation of proteasome-mediated protein degradation during oxidative stress and aging

Protein degradation is a physiological process required to maintain cellular functions...

Keywords: aging, oxidative stress, proteasome, protein degradation, protein oxidation

03/2008 | Biological Chemistry, Walter de Gruyter

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